Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM50173298
Substrate
n/a
Meas. Tech.
ChEMBL_321349 (CHEMBL880663)
IC50
13±n/a nM
Citation
 Venkatesan, AM; Grosu, GT; Failli, AA; Chan, PS; Coupet, J; Saunders, T; Mazandarani, H; Ru, X (4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators. Bioorg Med Chem Lett 15:5003-6 (2005) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50173298
Synonyms:
Biphenyl-4-yl-(3-dimethylaminomethyl-5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)-methanone | CHEMBL371721
Type:
Small organic molecule
Emp. Form.:
C28H27N3O
Mol. Mass.:
421.5335
SMILES:
CN(C)Cc1ccc2CN(C(=O)c3ccc(cc3)-c3ccccc3)c3ccccc3Cn12
Structure:
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