Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50173299
Substrate
n/a
Meas. Tech.
ChEMBL_321513 (CHEMBL880573)
IC50
2500±n/a nM
Citation
 Venkatesan, AM; Grosu, GT; Failli, AA; Chan, PS; Coupet, J; Saunders, T; Mazandarani, H; Ru, X (4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators. Bioorg Med Chem Lett 15:5003-6 (2005) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50173299
Synonyms:
(5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)-(3',5'-difluoro-biphenyl-4-yl)-methanone | CHEMBL372766
Type:
Small organic molecule
Emp. Form.:
C25H18F2N2O
Mol. Mass.:
400.42
SMILES:
Fc1cc(F)cc(c1)-c1ccc(cc1)C(=O)N1Cc2cccn2Cc2ccccc12
Structure:
Search PDB for entries with ligand similarity: