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Target
Histone-lysine N-methyltransferase SETD7
Ligand
BDBM50597859
Substrate
n/a
Meas. Tech.
ChEMBL_2224718 (CHEMBL5138231)
IC50
>10000±n/a nM
Citation
 Talukdar, A; Mukherjee, A; Bhattacharya, D Fascinating Transformation of SAM-Competitive Protein Methyltransferase Inhibitors from Nucleoside Analogues to Non-Nucleoside Analogues. J Med Chem 65:1662-1684 (2022) [PubMed] 
Target
Name:
Histone-lysine N-methyltransferase SETD7
Synonyms:
Histone-lysine N-methyltransferase SETD7 | KIAA1717 | KMT7 | SET domain-containing protein 7/9 (Set7/9) | SET7 | SET9 | SETD7 | SETD7_HUMAN
Type:
Enzyme
Mol. Mass.:
40691.12
Organism:
Homo sapiens (Human)
Description:
Q8WTS6
Residue:
366
Sequence:
MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
  
Inhibitor
Name:
BDBM50597859
Synonyms:
CHEMBL5197135
Type:
Small organic molecule
Emp. Form.:
C22H38N8O5
Mol. Mass.:
494.5877
SMILES:
CCCCCCNCCN(CC[C@H](N)C(O)=O)C[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
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