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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50174993
Substrate
n/a
Meas. Tech.
ChEMBL_326591 (CHEMBL862987)
IC50
2.1±n/a nM
Citation
 Zhao, C; Sham, HL; Sun, M; Stoll, VS; Stewart, KD; Lin, S; Mo, H; Vasavanonda, S; Saldivar, A; Park, C; McDonald, EJ; Marsh, KC; Klein, LL; Kempf, DJ; Norbeck, DW Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains. Bioorg Med Chem Lett 15:5499-503 (2005) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50174993
Synonyms:
(5R,6R)-2,4-bis(4-hydroxy-3-methoxybenzyl)-5-benzyl-6-hydroxy-1-(5-morpholinopentanoyl)-1,2,4-triazepan-3-one | CHEMBL200296
Type:
Small organic molecule
Emp. Form.:
C36H46N4O8
Mol. Mass.:
662.7724
SMILES:
COc1cc(CN2[C@H](Cc3ccccc3)[C@H](O)CN(N(Cc3ccc(O)c(OC)c3)C2=O)C(=O)CCCCN2CCOCC2)ccc1O
Structure:
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