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Target
M-phase inducer phosphatase 3
Ligand
BDBM50175219
Substrate
n/a
Meas. Tech.
ChEMBL_328904 (CHEMBL858783)
IC50
230±n/a nM
Citation
 Lavergne, O; Fernandes, AC; Bréhu, L; Sidhu, A; Brézak, MC; Prévost, G; Ducommun, B; Contour-Galcera, MO Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. Bioorg Med Chem Lett 16:171-5 (2005) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 3
Synonyms:
CDC25C | Dual specificity phosphatase Cdc25C | M-phase inducer phosphatase 3 | MPIP3_HUMAN
Type:
Substrate
Mol. Mass.:
53366.11
Organism:
Homo sapiens (Human)
Description:
P30307
Residue:
473
Sequence:
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
  
Inhibitor
Name:
BDBM50175219
Synonyms:
6-(2-(dimethylamino)ethylamino)-2-phenylbenzo[d]oxazole-4,7-dione | CHEMBL200805
Type:
Small organic molecule
Emp. Form.:
C17H17N3O3
Mol. Mass.:
311.3352
SMILES:
CN(C)CC=Nc1cc(O)c2nc(oc2c1O)-c1ccccc1 |w:5.5|
Structure:
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