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Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM50598628
Substrate
n/a
Meas. Tech.
ChEMBL_2227578 (CHEMBL5141091)
Ki
38100±n/a nM
Citation
 Fiorentino, F; Castiello, C; Mai, A; Rotili, D Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5. J Med Chem 65:9580-9606 (2022) [PubMed] 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM50598628
Synonyms:
CHEMBL5194061
Type:
Small organic molecule
Emp. Form.:
C59H81N11O17
Mol. Mass.:
1216.3379
SMILES:
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)c1ccccc1)C(C)C)C(=O)N[C@@H](CCCCNC(=O)C[C@H](NC(=O)OCc1ccccc1)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](C(C)C)C(N)=O |r|
Structure:
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