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Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM50598637
Substrate
n/a
Meas. Tech.
ChEMBL_2227583 (CHEMBL5141096)
IC50
290±n/a nM
Citation
 Fiorentino, F; Castiello, C; Mai, A; Rotili, D Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5. J Med Chem 65:9580-9606 (2022) [PubMed] 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM50598637
Synonyms:
CHEMBL5185695
Type:
Small organic molecule
Emp. Form.:
C33H40FN7O6S2
Mol. Mass.:
713.842
SMILES:
Oc1cc(CCNC(=S)NCCCC[C@H](NS(=O)(=O)c2cccc(F)c2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NC2CCC2)no1 |r|
Structure:
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