Reaction Details Report a problem with these data
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM50598638
Substrate
n/a
Meas. Tech.
ChEMBL_2227584 (CHEMBL5141097)
Ki
0.500000±n/a nM
Citation
 Fiorentino, F; Castiello, C; Mai, A; Rotili, D Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5. J Med Chem 65:9580-9606 (2022) [PubMed] 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM50598638
Synonyms:
CHEMBL5199270
Type:
Small organic molecule
Emp. Form.:
C31H39FN10O4S2
Mol. Mass.:
698.834
SMILES:
Fc1cccc(c1)S(=O)(=O)N[C@@H](CCCCNC(=S)NCCc1nnn[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC1CCC1 |r|
Structure:
Search PDB for entries with ligand similarity: