Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50598700
Substrate
n/a
Meas. Tech.
ChEMBL_2227759 (CHEMBL5141272)
Ki
0.044000±n/a nM
Citation
 Rosse, G Spiro-naphthyridine Antagonists of the Melanocortin Receptor 4 for the Treatment of Cachexia Associated with Chronic Illness. ACS Med Chem Lett 13:997-998 (2022) [PubMed] 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50598700
Synonyms:
CHEMBL5194472
Type:
Small organic molecule
Emp. Form.:
C27H33N5O3
Mol. Mass.:
475.5826
SMILES:
COc1cc(OC)cc(c1)[C@@H](C)C(=O)N1CC[C@]2(C1)CCc1cc(-c3cnn(C)c3)c(C)nc1N2 |r|
Structure:
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