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Target
Cathepsin B
Ligand
BDBM50002398
Substrate
n/a
Meas. Tech.
ChEMBL_321688 (CHEMBL872183)
Ki
>1000±n/a nM
Citation
 Marquis, RW; James, I; Zeng, J; Trout, RE; Thompson, S; Rahman, A; Yamashita, DS; Xie, R; Ru, Y; Gress, CJ; Blake, S; Lark, MA; Hwang, SM; Tomaszek, T; Offen, P; Head, MS; Cummings, MD; Veber, DF Azepanone-based inhibitors of human cathepsin L. J Med Chem 48:6870-8 (2005) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50002398
Synonyms:
CHEMBL196023
Type:
Small organic molecule
Emp. Form.:
C27H31N5O5S
Mol. Mass.:
537.631
SMILES:
CC(C)C[C@H](NC(=O)c1cccc2cccnc12)C(=O)N[C@H]1CCCN(CC1=O)S(=O)(=O)c1ccccn1
Structure:
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