Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50176277
Substrate
n/a
Meas. Tech.
ChEMBL_328397 (CHEMBL863960)
IC50
400±n/a nM
Citation
Laporte, MG; Lessen, TA; Leister, L; Cebzanov, D; Amparo, E; Faust, C; Ortlip, D; Bailey, TR; Nitz, TJ; Chunduru, SK; Young, DC; Burns, CJ Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase. Bioorg Med Chem Lett 16:100-3 (2005) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50176277
Synonyms:
CHEMBL200046 | ethyl 6,6-dimethyl-2-(3-(pyrrolidin-1-ylsulfonyl)ureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H27N3O5S2
Mol. Mass.:
429.554
SMILES:
CCOC(=O)c1c(NC(=O)NS(=O)(=O)N2CCCC2)sc2CC(C)(C)CCc12