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Target
Proteasome subunit beta type-2
Ligand
BDBM50599554
Substrate
n/a
Meas. Tech.
ChEMBL_2230873 (CHEMBL5144645)
Ki
3000±n/a nM
Citation
 Ettari, R; Iraci, N; Di Chio, C; Previti, S; Danzč, M; Zappalą, M Development of isoquinolinone derivatives as immunoproteasome inhibitors. Bioorg Med Chem Lett 55:0 (2022) [PubMed] 
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50599554
Synonyms:
CHEMBL5172870
Type:
Small organic molecule
Emp. Form.:
C24H26N2O4
Mol. Mass.:
406.4742
SMILES:
COc1cc2ccn(C\C=C\C(=O)NCCCc3ccccc3)c(=O)c2cc1OC
Structure:
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