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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50178767
Substrate
n/a
Meas. Tech.
ChEMBL_325280 (CHEMBL859691)
IC50
>100000±n/a nM
Citation
 Napper, AD; Hixon, J; McDonagh, T; Keavey, K; Pons, JF; Barker, J; Yau, WT; Amouzegh, P; Flegg, A; Hamelin, E; Thomas, RJ; Kates, M; Jones, S; Navia, MA; Saunders, JO; DiStefano, PS; Curtis, R Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem 48:8045-54 (2005) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50178767
Synonyms:
2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CHEMBL112265
Type:
Small organic molecule
Emp. Form.:
C13H14N2O
Mol. Mass.:
214.2631
SMILES:
NC(=O)C1CCCc2c1[nH]c1ccccc21
Structure:
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