Reaction Details Report a problem with these data
Target
Eukaryotic elongation factor 2 kinase
Ligand
BDBM50375667
Substrate
n/a
Meas. Tech.
ChEMBL_2234268 (CHEMBL5148040)
IC50
440±n/a nM
Citation
 Liu, Z; Jiang, A; Wang, Y; Xu, P; Zhang, Q; Wang, Y; He, S; Wang, N; Jin, H; Zhang, B In silico, synthesis and anticancer evaluation of benzamide tryptamine derivatives as novel eEF2K inhibitors. Bioorg Med Chem Lett 67:0 (2022) [PubMed] 
Target
Name:
Eukaryotic elongation factor 2 kinase
Synonyms:
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K
Type:
Protein
Mol. Mass.:
82116.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
725
Sequence:
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE
  
Inhibitor
Name:
BDBM50375667
Synonyms:
CHEMBL437612 | TX-1918
Type:
Small organic molecule
Emp. Form.:
C14H12O3
Mol. Mass.:
228.2433
SMILES:
[#6]-c1cc(\[#6]=[#6]-2\[#6](=O)-[#6]=[#6]-[#6]-2=O)cc(-[#6])c1-[#8] |c:8|
Structure:
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