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Target
Ribosomal protein S6 kinase alpha-5
Ligand
BDBM50601141
Substrate
n/a
Meas. Tech.
ChEMBL_2235865 (CHEMBL5149637)
IC50
32±n/a nM
Citation
 Hall, A; Abendroth, J; Bolejack, MJ; Ceska, T; Dell'Aiera, S; Ellis, V; Fox, D; François, C; Muruthi, MM; Prével, C; Poullennec, K; Romanov, S; Valade, A; Vanbellinghen, A; Yano, J; Geraerts, M Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1. ACS Med Chem Lett 13:1099-1108 (2022) [PubMed] 
Target
Name:
Ribosomal protein S6 kinase alpha-5
Synonyms:
90 kDa ribosomal protein S6 kinase 5 | KS6A5_HUMAN | MSK1 | Mitogen- and Stress-Activated Protein Kinase 1 (MSK1) | Nuclear mitogen- and stress-activated protein kinase 1 | Nuclear mitogen- and stress-activated protein kinase 1 (MSK1) | RPS6KA5 | RPS6KA5(Kin.Dom.2 - C-terminal) | RSK-like protein kinase | RSKL | Ribosomal protein S6 kinase | Ribosomal protein S6 kinase alpha 5 | Ribosomal protein S6 kinase alpha-5
Type:
Serine/threonine-protein kinase
Mol. Mass.:
89874.44
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
802
Sequence:
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFSDSVA
  
Inhibitor
Name:
BDBM50601141
Synonyms:
CHEMBL5191167
Type:
Small organic molecule
Emp. Form.:
C10H5Cl2N5
Mol. Mass.:
266.086
SMILES:
Clc1cnc(Cl)nc1-n1ccc2ncncc12
Structure:
Search PDB for entries with ligand similarity: