Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50601277
Substrate
n/a
Meas. Tech.
ChEMBL_2236109 (CHEMBL5149881)
IC50
2.0±n/a nM
Citation
 Dong, X; Liang, Q; Pan, YZ; Wang, X; Kuo, YC; Chiang, WC; Zhang, X; Williams, NS; Rizo, J; Levine, B; De Brabander, JK Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction. ACS Med Chem Lett 13:1510-1516 (2022) [PubMed] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50601277
Synonyms:
CHEMBL5183315
Type:
Small organic molecule
Emp. Form.:
C26H25BrN4O3
Mol. Mass.:
521.406
SMILES:
CC(C)OC(=O)Nc1ccc(cn1)C1=NN(C(C1C)c1ccccc1)C(=O)c1ccc(Br)cc1 |t:14|
Structure:
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