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Target
Methionine aminopeptidase
Ligand
BDBM50180731
Substrate
n/a
Meas. Tech.
ChEMBL_329657 (CHEMBL865844)
IC50
105±n/a nM
Citation
 Schiffmann, R; Neugebauer, A; Klein, CD Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions. J Med Chem 49:511-22 (2006) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM50180731
Synonyms:
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine | 2-pyridin-2-yl-1H-imidazo[4,5-b]pyridine | CHEMBL371481
Type:
Small organic molecule
Emp. Form.:
C11H8N4
Mol. Mass.:
196.208
SMILES:
c1ccc(nc1)-c1nc2ncccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: