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Target
GTPase HRas
Ligand
BDBM50601398
Substrate
n/a
Meas. Tech.
ChEMBL_2236258 (CHEMBL5150154)
IC50
100±n/a nM
Citation
 Korzeniecki, C; Priefer, R Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway. Eur J Med Chem 211:0 (2021) [PubMed] 
Target
Name:
GTPase HRas
Synonyms:
GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:
Other Protein Type
Mol. Mass.:
21293.37
Organism:
Homo sapiens (Human)
Description:
P01112
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
  
Inhibitor
Name:
BDBM50601398
Synonyms:
CHEMBL5174384
Type:
Small organic molecule
Emp. Form.:
C25H42N2O6S2
Mol. Mass.:
530.741
SMILES:
CCC(C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)CC(CCS(C)(=O)=O)C(=O)OC)NC[C@@H](N)CS |r|
Structure:
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