Reaction Details Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase A
Ligand
BDBM50181487
Substrate
n/a
Meas. Tech.
ChEMBL_330335 (CHEMBL869970)
IC50
499±n/a nM
Citation
 Guichou, JF; Viaud, J; Mettling, C; Subra, G; Lin, YL; Chavanieu, A Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A. J Med Chem 49:900-10 (2006) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase A
Synonyms:
CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A
Type:
Protein
Mol. Mass.:
18015.32
Organism:
Homo sapiens (Human)
Description:
P62937
Residue:
165
Sequence:
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
  
Inhibitor
Name:
BDBM50181487
Synonyms:
1-(3-benzyloxy-pyridin-2-yl)-3-(4-trifluoromethyl-phenyl)-urea | CHEMBL382465
Type:
Small organic molecule
Emp. Form.:
C20H16F3N3O2
Mol. Mass.:
387.3551
SMILES:
FC(F)(F)c1ccc(NC(=O)Nc2ncccc2OCc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: