Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50601998
Substrate
n/a
Meas. Tech.
ChEMBL_2238889 (CHEMBL5152785)
Kd
74±n/a nM
Citation
 Amin, TU; Emara, R; Pal, A; Aldawod, H; Jiang, G; Liang, D; Haque Tuhin, MT; Balgoname, A; Patel, AD; Alhamadsheh, MM Enhancing the Safety and Efficacy of PSMA-Based Small-Molecule Drug Conjugates by Linker Stabilization and Conjugation to Transthyretin Binding Ligand. J Med Chem 65:15473-15486 (2022) [PubMed] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50601998
Synonyms:
CHEMBL5205181
Type:
Small organic molecule
Emp. Form.:
C27H42N6O6
Mol. Mass.:
546.659
SMILES:
Cc1n[nH]c(C)c1CCCOc1cc(OCCCCCCNCCOCCOCCN=[N+]=[N-])cc(c1)C(O)=O
Structure:
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