Reaction Details Report a problem with these data
Target
P2Y purinoceptor 14
Ligand
BDBM50456168
Substrate
n/a
Meas. Tech.
ChEMBL_2239232 (CHEMBL5153128)
IC50
2.0±n/a nM
Citation
 Wang, YH; Zhou, MZ; Ye, T; Wang, PP; Lu, R; Wang, YL; Liu, CX; Xiao, W; Li, JY; Meng, ZB; Xu, LL; Hu, QH; Jiang, C Discovery of a Series of 5-Amide-1 J Med Chem 65:15967-15990 (2022) [PubMed] 
Target
Name:
P2Y purinoceptor 14
Synonyms:
GPR105 | Insulin Receptor-Related Protein (INSRR) | KIAA0001 | P2RY14 | P2Y14_HUMAN | Purinergic receptor P2Y14
Type:
PROTEIN
Mol. Mass.:
38991.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502487
Residue:
338
Sequence:
MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
  
Inhibitor
Name:
BDBM50456168
Synonyms:
CHEMBL1800685
Type:
Small organic molecule
Emp. Form.:
C29H24F3NO2
Mol. Mass.:
475.5016
SMILES:
OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Structure:
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