Reaction Details Report a problem with these data
Target
P2Y purinoceptor 6
Ligand
BDBM50454137
Substrate
n/a
Meas. Tech.
ChEMBL_2239236 (CHEMBL5153132)
IC50
39450±n/a nM
Citation
 Wang, YH; Zhou, MZ; Ye, T; Wang, PP; Lu, R; Wang, YL; Liu, CX; Xiao, W; Li, JY; Meng, ZB; Xu, LL; Hu, QH; Jiang, C Discovery of a Series of 5-Amide-1 J Med Chem 65:15967-15990 (2022) [PubMed] 
Target
Name:
P2Y purinoceptor 6
Synonyms:
P2RY6 | P2RY6_HUMAN | P2Y purinoceptor 6 | P2Y6 | Pyrimidinergic receptor P2Y6
Type:
PROTEIN
Mol. Mass.:
36452.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1511151
Residue:
328
Sequence:
MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR
  
Inhibitor
Name:
BDBM50454137
Synonyms:
CHEMBL1321988
Type:
Small organic molecule
Emp. Form.:
C20H20N6S4
Mol. Mass.:
472.673
SMILES:
S=C=Nc1cccc(NC(=S)NCCCCNC(=S)Nc2cccc(c2)N=C=S)c1
Structure:
Search PDB for entries with ligand similarity: