Target
Microsomal triglyceride transfer protein large subunit
Ligand
BDBM50184103
Substrate
n/a
Meas. Tech.
ChEMBL_364710 (CHEMBL866306)
IC50
26.8±n/a nM
Citation
 Li, JBertinato, PCheng, HCole, BMBronk, BSJaynes, BHHickman, AHaven, MLKolosko, NLBarry, CJManion, TB Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents. Bioorg Med Chem Lett 16:3039-42 (2006) [PubMed]  Article 
Target
Name:
Microsomal triglyceride transfer protein large subunit
Synonyms:
MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit
Type:
PROTEIN
Mol. Mass.:
99365.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_971724
Residue:
894
Sequence:
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
  
Inhibitor
Name:
BDBM50184103
Synonyms:
1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dihydro-1H-indole-5-carboxylic acid ((S)-benzylcarbamoyl-phenyl-methyl)-amide | CHEMBL383621
Type:
Small organic molecule
Emp. Form.:
C38H30F3N3O3
Mol. Mass.:
633.6583
SMILES:
FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)N1CCc2cc(ccc12)C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: