Reaction Details Report a problem with these data
Target
Protein kinase C alpha type
Ligand
BDBM50184393
Substrate
n/a
Meas. Tech.
ChEMBL_338717 (CHEMBL860607)
Ki
21700±n/a nM
Citation
 Lee, J; Kang, JH; Han, KC; Kim, Y; Kim, SY; Youn, HS; Mook-Jung, I; Kim, H; Lo Han, JH; Ha, HJ; Kim, YH; Marquez, VE; Lewin, NE; Pearce, LV; Lundberg, DJ; Blumberg, PM Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators. J Med Chem 49:2028-36 (2006) [PubMed]  Article 
Target
Name:
Protein kinase C alpha type
Synonyms:
KPCA_HUMAN | PKC alpha | PKC alpha and beta-2 | PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein Kinase C- alpha | Protein kinase C alpha | Protein kinase C alpha (PKCa) | Protein kinase C alpha type (PKC-A) | Protein kinase C alpha type (PRKCA) | Proto-oncogene c-RAF | RAF proto-oncogene serine/threonine-protein kinase
Type:
Enzyme
Mol. Mass.:
76755.65
Organism:
Homo sapiens (Human)
Description:
The recombinant human PKC enzymes were produced using a baculovirus expression system in SF9 cells
Residue:
672
Sequence:
MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
  
Inhibitor
Name:
BDBM50184393
Synonyms:
5-[(Z)-3-(tert-butoxy)-3-oxo-1-propenyl]-5-hydroxymethyl-3-[(E)-3-isobutyl-5-methylhexylidene]tetrahydro-2-furanone | CHEMBL436943
Type:
Small organic molecule
Emp. Form.:
C23H38O5
Mol. Mass.:
394.5448
SMILES:
CC(C)CC(C\C=C1/CC(CO)(OC1=O)\C=C/C(=O)OC(C)(C)C)CC(C)C
Structure:
Search PDB for entries with ligand similarity: