Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM50184499
Substrate
n/a
Meas. Tech.
ChEMBL_365134 (CHEMBL867497)
IC50
>100000±n/a nM
Citation
 Miyazaki, Y; Kato, Y; Manabe, T; Shimada, H; Mizuno, M; Egusa, T; Ohkouchi, M; Shiromizu, I; Matsusue, T; Yamamoto, I Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. Bioorg Med Chem Lett 16:2986-90 (2006) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50184499
Synonyms:
CHEMBL208638 | N-(2-(3-(4-(aminomethyl)phenyl)propylamino)ethyl)-1-chloronaphthalene-2-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C22H26ClN3O2S
Mol. Mass.:
431.979
SMILES:
NCc1ccc(CCCNCCNS(=O)(=O)c2ccc3ccccc3c2Cl)cc1
Structure:
Search PDB for entries with ligand similarity: