Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-4
Ligand
BDBM50185633
Substrate
n/a
Meas. Tech.
ChEMBL_361597 (CHEMBL859725)
Ki
315000±n/a nM
Citation
 Basse, N; Papapostolou, D; Pagano, M; Reboud-Ravaux, M; Bernard, E; Felten, AS; Vanderesse, R Development of lipopeptides for inhibiting 20S proteasomes. Bioorg Med Chem Lett 16:3277-81 (2006) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-4
Synonyms:
PRE1 | PSB4_YEAST | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22515.40
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_361597
Residue:
198
Sequence:
MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQIDYLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQAQ
  
Inhibitor
Name:
BDBM50185633
Synonyms:
(S)-2-((S)-6-amino-2-((S)-2-((2S,3R)-2-((S)-2-((2S,3R)-2-hexanamido-3-hydroxybutanamido)-3-methylbutanamido)-3-hydroxybutanamido)-3-(4-hydroxyphenyl)propanamido)hexanamido)-3-phenylpropanoic acid | CHEMBL207660
Type:
Small organic molecule
Emp. Form.:
C43H65N7O11
Mol. Mass.:
856.0165
SMILES:
CCCCCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Structure:
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