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Target
RNA-directed RNA polymerase
Ligand
BDBM50186156
Substrate
n/a
Meas. Tech.
ChEMBL_369597 (CHEMBL865370)
IC50
5.2±n/a nM
Citation
Chris Krueger, A; Madigan, DL; Jiang, WW; Kati, WM; Liu, D; Liu, Y; Maring, CJ; Masse, S; McDaniel, KF; Middleton, T; Mo, H; Molla, A; Montgomery, D; Pratt, JK; Rockway, TW; Zhang, R; Kempf, DJ Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides. Bioorg Med Chem Lett 16:3367-70 (2006) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50186156
Synonyms:
CHEMBL379613 | N-{3-[1-(cyclobutylamino)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxo-2H-1,2,4-benzothiadiazin-7-yl}aminosulfonamide
Type:
Small organic molecule
Emp. Form.:
C20H20N6O6S2
Mol. Mass.:
504.539
SMILES:
NS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)c1c(O)c2ccccc2n(NC2CCC2)c1=O |c:9|