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Target
RNA-directed RNA polymerase
Ligand
BDBM50186206
Substrate
n/a
Meas. Tech.
ChEMBL_366543 (CHEMBL871397)
IC50
5±n/a nM
Citation
 Rockway, TW; Zhang, R; Liu, D; Betebenner, DA; McDaniel, KF; Pratt, JK; Beno, D; Montgomery, D; Jiang, WW; Masse, S; Kati, WM; Middleton, T; Molla, A; Maring, CJ; Kempf, DJ Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring. Bioorg Med Chem Lett 16:3833-8 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50186206
Synonyms:
Bbutane-1-sulfonic acid {3-[4-hydroxy-1-(3-methyl-butyl)-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl]-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-7-yl}-amide | CHEMBL212355 | butane-1-sulfonic acid {3-[4-hydroxy-1-(3-methyl-butyl)-2-oxo-1,2-dihydro-quinolin-3-yl]-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-7-yl}-amide
Type:
Small organic molecule
Emp. Form.:
C24H29N5O6S2
Mol. Mass.:
547.647
SMILES:
CCCCS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)c1c(O)c2cccnc2n(CCC(C)C)c1=O |c:12|
Structure:
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