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Target
Cyclin-dependent kinase 2
Ligand
BDBM50186460
Substrate
n/a
Meas. Tech.
ChEMBL_377347 (CHEMBL865410)
IC50
29000±n/a nM
Citation
 Das, J; Furch, JA; Liu, C; Moquin, RV; Lin, J; Spergel, SH; McIntyre, KW; Shuster, DJ; O'Day, KD; Penhallow, B; Hung, CY; Doweyko, AM; Kamath, A; Zhang, H; Marathe, P; Kanner, SB; Lin, TA; Dodd, JH; Barrish, JC; Wityak, J Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett 16:3706-12 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50186460
Synonyms:
CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbonyl)-4-methoxy-2-methylphenylthio)thiazol-2-yl)-4-((3,3-dimethylbutan-2-ylamino)methyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C32H41N5O4S2
Mol. Mass.:
623.829
SMILES:
COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(CNC(C)C(C)(C)C)cc3)s2)cc1C(=O)N1CCN(CC1)C(C)=O
Structure:
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