Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM50055366
Substrate
n/a
Meas. Tech.
ChEMBL_352633 (CHEMBL862123)
IC50
140±n/a nM
Citation
 Smart, BP; Oslund, RC; Walsh, LA; Gelb, MH The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding. J Med Chem 49:2858-60 (2006) [PubMed]  Article 
Target
Name:
Phospholipase A2
Synonyms:
PA21B_MOUSE | Phospholipase A2 group 1B | Pla2 | Pla2g1b
Type:
PROTEIN
Mol. Mass.:
16291.94
Organism:
Mus musculus
Description:
ChEMBL_489269
Residue:
146
Sequence:
MKLLLLAALLTAGAAAHSISPRAVWQFRNMIKCTIPGSDPLKDYNNYGCYCGLGGWGTPVDDLDRCCQTHDHCYSQAKKLESCKFLIDNPYTNTYSYSCSGSEITCSAKNNKCEDFICNCDREAAICFSKVPYNKEYKNLDTGKFC
  
Inhibitor
Name:
BDBM50055366
Synonyms:
(3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-acetic acid | (3-Aminooxalyl-1-benzyl-2-ethyl-2,3-dihydro-1H-indol-4-yloxy)-acetic acid | 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid | CHEMBL148674 | Varespladib sodium
Type:
Small organic molecule
Emp. Form.:
C21H20N2O5
Mol. Mass.:
380.3939
SMILES:
CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Structure:
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