Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186823
Substrate
n/a
Meas. Tech.
ChEMBL_376573 (CHEMBL866622)
Ki
20±n/a nM
Citation
 Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3674-8 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186823
Synonyms:
4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-[1-(thiophene-2-carbonyl)-piperidin-4-ylidene]-methyl}-biphenyl-3-carbonitrile | CHEMBL377864
Type:
Small organic molecule
Emp. Form.:
C32H22F4N4OS
Mol. Mass.:
586.602
SMILES:
Fc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCN(CC1)C(=O)c1cccs1)c1ccc(cc1)-c1cccc(c1)C#N |(26.9,-17.52,;26.14,-18.86,;24.61,-18.86,;23.84,-20.19,;22.34,-20.51,;22.18,-22.04,;23.59,-22.66,;24.61,-21.52,;26.14,-21.52,;26.91,-20.19,;28.45,-20.19,;29.99,-20.19,;28.45,-21.73,;28.45,-18.65,;20.85,-22.81,;20.85,-24.35,;19.51,-25.11,;19.51,-26.65,;20.84,-27.42,;22.18,-26.65,;22.18,-25.11,;20.84,-28.96,;22.17,-29.73,;19.5,-29.73,;18.1,-29.1,;17.07,-30.25,;17.83,-31.58,;19.34,-31.27,;19.51,-22.04,;18.17,-22.81,;16.84,-22.04,;16.84,-20.5,;18.17,-19.73,;19.51,-20.49,;15.51,-19.73,;14.19,-20.5,;12.85,-19.74,;12.85,-18.19,;14.18,-17.42,;15.51,-18.19,;14.17,-15.88,;14.17,-14.34,)|
Structure:
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