Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186828
Substrate
n/a
Meas. Tech.
ChEMBL_376573 (CHEMBL866622)
Ki
26±n/a nM
Citation
 Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3674-8 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186828
Synonyms:
CHEMBL378310 | {4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methyl]-biphenyl-3-yl}-acetonitrile
Type:
Small organic molecule
Emp. Form.:
C32H28F4N4
Mol. Mass.:
544.5851
SMILES:
Fc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCN(CC2CC2)CC1)c1ccc(cc1)-c1cccc(CC#N)c1 |(6.16,-16.51,;5.39,-17.84,;3.86,-17.85,;3.09,-19.17,;1.59,-19.49,;1.43,-21.02,;2.84,-21.65,;3.86,-20.5,;5.39,-20.5,;6.16,-19.18,;7.7,-19.18,;9.24,-19.17,;7.7,-20.72,;7.7,-17.64,;.1,-21.79,;.1,-23.33,;-1.24,-24.1,;-1.24,-25.63,;.09,-26.4,;.09,-27.94,;-1.25,-28.71,;-2.78,-28.71,;-2.01,-30.05,;1.43,-25.63,;1.43,-24.09,;-1.24,-21.03,;-2.57,-21.8,;-3.91,-21.03,;-3.9,-19.48,;-2.58,-18.71,;-1.24,-19.48,;-5.24,-18.71,;-6.56,-19.48,;-7.89,-18.72,;-7.9,-17.17,;-6.57,-16.4,;-6.57,-14.86,;-5.23,-14.09,;-3.9,-13.32,;-5.23,-17.17,)|
Structure:
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