Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186830
Substrate
n/a
Meas. Tech.
ChEMBL_376573 (CHEMBL866622)
Ki
15±n/a nM
Citation
 Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3674-8 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186830
Synonyms:
4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5,6-dichloro-1H-benzoimidazol-2-yl)-methyl]-biphenyl-3-carbonitrile | CHEMBL211820
Type:
Small organic molecule
Emp. Form.:
C30H26Cl2N4
Mol. Mass.:
513.46
SMILES:
Clc1cc2nc([nH]c2cc1Cl)C(=C1CCN(CC2CC2)CC1)c1ccc(cc1)-c1cccc(c1)C#N |(7.77,-.56,;6.23,-.56,;5.46,-1.89,;3.93,-1.89,;2.91,-3.04,;1.5,-2.41,;1.66,-.88,;3.17,-.56,;3.93,.77,;5.46,.77,;6.23,2.1,;.17,-3.18,;.17,-4.72,;-1.16,-5.48,;-1.17,-7.02,;.17,-7.79,;.16,-9.33,;-1.17,-10.1,;-2.71,-10.1,;-1.94,-11.44,;1.5,-7.02,;1.51,-5.48,;-1.16,-2.41,;-2.5,-3.19,;-3.83,-2.42,;-3.83,-.87,;-2.5,-.1,;-1.17,-.87,;-5.16,-.1,;-6.49,-.87,;-7.82,-.11,;-7.83,1.44,;-6.49,2.21,;-5.16,1.44,;-6.49,3.75,;-6.49,5.29,)|
Structure:
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