Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186839
Substrate
n/a
Meas. Tech.
ChEMBL_376573 (CHEMBL866622)
Ki
22±n/a nM
Citation
 Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3674-8 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186839
Synonyms:
4-[(3'-cyano-biphenyl-4-yl)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methylene]-piperidine-1-carboxylic acid diethylamide | CHEMBL211615
Type:
Small organic molecule
Emp. Form.:
C32H29F4N5O
Mol. Mass.:
575.5992
SMILES:
CCN(CC)C(=O)N1CCC(CC1)=C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)c1ccc(cc1)-c1cccc(c1)C#N |(-.05,-44.81,;1.29,-44.05,;1.29,-42.51,;-.04,-41.73,;-1.38,-42.5,;2.62,-41.74,;3.96,-42.51,;2.63,-40.2,;1.3,-39.43,;1.3,-37.89,;2.64,-37.13,;3.97,-37.89,;3.96,-39.43,;2.63,-35.59,;3.97,-34.82,;5.37,-35.44,;6.39,-34.3,;7.93,-34.3,;8.7,-32.97,;7.92,-31.64,;8.69,-30.3,;6.39,-31.64,;5.63,-32.96,;4.12,-33.29,;10.24,-32.97,;11.78,-32.97,;10.24,-34.51,;10.24,-31.43,;1.3,-34.82,;-.04,-35.59,;-1.37,-34.82,;-1.37,-33.28,;-.04,-32.51,;1.29,-33.27,;-2.7,-32.51,;-4.03,-33.28,;-5.36,-32.52,;-5.37,-30.97,;-4.03,-30.2,;-2.7,-30.97,;-4.04,-28.66,;-4.04,-27.12,)|
Structure:
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