Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186842
Substrate
n/a
Meas. Tech.
ChEMBL_376573 (CHEMBL866622)
Ki
31±n/a nM
Citation
 Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3674-8 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186842
Synonyms:
4'-[(1-cyclopropanecarbonyl-piperidin-4-ylidene)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methyl]-biphenyl-3-carbonitrile | CHEMBL211511
Type:
Small organic molecule
Emp. Form.:
C31H24F4N4O
Mol. Mass.:
544.5421
SMILES:
Fc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCN(CC1)C(=O)C1CC1)c1ccc(cc1)-c1cccc(c1)C#N |(7.48,-18.01,;6.72,-19.35,;5.19,-19.35,;4.42,-20.67,;2.92,-20.99,;2.76,-22.53,;4.17,-23.15,;5.19,-22,;6.72,-22.01,;7.49,-20.68,;9.03,-20.68,;10.57,-20.67,;9.03,-22.22,;9.03,-19.14,;1.43,-23.3,;1.43,-24.84,;.09,-25.6,;.09,-27.13,;1.42,-27.91,;2.76,-27.14,;2.76,-25.59,;1.42,-29.45,;2.75,-30.22,;.08,-30.22,;-1.45,-30.22,;-.69,-31.55,;.09,-22.53,;-1.24,-23.3,;-2.58,-22.53,;-2.57,-20.99,;-1.25,-20.22,;.09,-20.98,;-3.91,-20.22,;-5.23,-20.99,;-6.57,-20.22,;-6.57,-18.68,;-5.24,-17.91,;-3.9,-18.68,;-5.24,-16.37,;-5.24,-14.83,)|
Structure:
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