Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186844
Substrate
n/a
Meas. Tech.
ChEMBL_376573 (CHEMBL866622)
Ki
31±n/a nM
Citation
 Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3674-8 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186844
Synonyms:
4'-[(1-acetyl-piperidin-4-ylidene)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methyl]-biphenyl-3-carbonitrile | CHEMBL208573
Type:
Small organic molecule
Emp. Form.:
C29H22F4N4O
Mol. Mass.:
518.5048
SMILES:
CC(=O)N1CCC(CC1)=C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)c1ccc(cc1)-c1cccc(c1)C#N |(19.68,-12.41,;21.01,-11.64,;22.34,-12.42,;21.01,-10.1,;19.68,-9.33,;19.68,-7.8,;21.02,-7.03,;22.35,-7.79,;22.35,-9.33,;21.02,-5.49,;22.35,-4.72,;23.76,-5.35,;24.78,-4.2,;26.31,-4.2,;27.08,-2.87,;26.31,-1.54,;27.08,-.21,;24.78,-1.54,;24.02,-2.87,;22.51,-3.19,;28.62,-2.87,;30.16,-2.87,;28.63,-4.41,;28.62,-1.33,;19.69,-4.73,;18.35,-5.5,;17.02,-4.73,;17.02,-3.18,;18.35,-2.41,;19.68,-3.18,;15.68,-2.41,;14.36,-3.18,;13.03,-2.42,;13.02,-.87,;14.36,-.1,;15.69,-.87,;14.35,1.44,;14.35,2.98,)|
Structure:
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