Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186847
Substrate
n/a
Meas. Tech.
ChEMBL_376573 (CHEMBL866622)
Ki
16±n/a nM
Citation
 Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3674-8 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186847
Synonyms:
2-{4-[(3'-cyano-biphenyl-4-yl)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methylene]-piperidin-1-yl}-acetamide | CHEMBL211069
Type:
Small organic molecule
Emp. Form.:
C29H23F4N5O
Mol. Mass.:
533.5194
SMILES:
NC(=O)CN1CCC(CC1)=C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)c1ccc(cc1)-c1cccc(c1)C#N |(20.24,-46.14,;20.24,-44.6,;18.91,-43.83,;21.58,-43.83,;21.58,-42.29,;20.25,-41.52,;20.25,-39.98,;21.59,-39.22,;22.92,-39.98,;22.92,-41.52,;21.59,-37.68,;22.92,-36.91,;24.33,-37.53,;25.35,-36.39,;26.88,-36.39,;27.65,-35.06,;26.88,-33.73,;27.64,-32.39,;25.35,-33.73,;24.58,-35.06,;23.08,-35.38,;29.19,-35.06,;30.73,-35.06,;29.19,-36.6,;29.19,-33.52,;20.25,-36.91,;18.92,-37.69,;17.58,-36.91,;17.58,-35.37,;18.91,-34.6,;20.25,-35.36,;16.25,-34.6,;14.93,-35.37,;13.59,-34.61,;13.59,-33.06,;14.92,-32.29,;16.26,-33.06,;14.92,-30.75,;14.92,-29.21,)|
Structure:
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