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Target
Glutaminase kidney isoform, mitochondrial
Ligand
BDBM50605215
Substrate
n/a
Meas. Tech.
ChEMBL_2250762 (CHEMBL5164972)
Kd
81±n/a nM
Citation
 Xu, X; Chang, X; Huang, J; Zhang, D; Wang, M; Jing, T; Zhuang, Y; Kou, J; Qiu, Z; Wang, J; Li, Z; Bian, J Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
Glutaminase kidney isoform, mitochondrial
Synonyms:
GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase
Type:
Protein
Mol. Mass.:
73471.89
Organism:
Homo sapiens (Human)
Description:
O94925
Residue:
669
Sequence:
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
  
Inhibitor
Name:
BDBM50605215
Synonyms:
CHEMBL5178036
Type:
Small organic molecule
Emp. Form.:
C30H30F3N11O3S2
Mol. Mass.:
713.756
SMILES:
CO[C@H](C(=O)Nc1nnc(NC2CCN(CC2)c2nnc(NC(=O)CCc3cn(nn3)-c3ccc(cc3)C(F)(F)F)s2)s1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: