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Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Ligand
BDBM50605605
Substrate
n/a
Meas. Tech.
ChEMBL_2252275 (CHEMBL5166485)
Kd
670±n/a nM
Citation
 Tian, Y; Shehata, MA; Gauger, SJ; Ng, CKL; Solbak, S; Thiesen, L; Bruus-Jensen, J; Krall, J; Bundgaard, C; Gibson, KM; Wellendorph, P; Frĝlund, B Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKII? Hub Domain. J Med Chem 65:6656-6676 (2022) [PubMed] 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:
CAMK2A | CAMKA | CaM kinase II | CaM kinase II alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2a) | KCC2A_HUMAN | KIAA0968
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54093.63
Organism:
Homo sapiens (Human)
Description:
gi_25952118
Residue:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
  
Inhibitor
Name:
BDBM50605605
Synonyms:
CHEMBL5198167
Type:
Small organic molecule
Emp. Form.:
C14H11ClN4O2
Mol. Mass.:
302.716
SMILES:
Oc1ccc(Oc2ccccc2Cl)c(Cc2nnn[nH]2)c1
Structure:
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