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Target
Protein AF-9
Ligand
BDBM50606141
Substrate
n/a
Meas. Tech.
ChEMBL_2253822 (CHEMBL5168032)
Ki
9.0±n/a nM
Citation
 Yuan, Y; Du, L; Tan, R; Yu, Y; Jiang, J; Yao, A; Luo, J; Tang, R; Xiao, Y; Sun, H Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. J Med Chem 65:7770-7785 (2022) [PubMed] 
Target
Name:
Protein AF-9
Synonyms:
AF9 | AF9_HUMAN | ALL1-fused gene from chromosome 9 protein | MLLT3 | Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein | Protein AF-9 | YEATS domain-containing protein 3 | YEATS3
Type:
PROTEIN
Mol. Mass.:
63368.78
Organism:
Homo sapiens
Description:
ChEMBL_118006
Residue:
568
Sequence:
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS
  
Inhibitor
Name:
BDBM50606141
Synonyms:
CHEMBL5187149
Type:
Small organic molecule
Emp. Form.:
C42H60N8O5
Mol. Mass.:
756.9764
SMILES:
CC(C)CCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N[C@@H](C)c1nc2cccc(-c3ccccc3)c2[nH]1 |r|
Structure:
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