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Target
Hypoxia-inducible factor 1-alpha inhibitor
Ligand
BDBM118339
Substrate
n/a
Meas. Tech.
ChEMBL_2260673 (CHEMBL5215684)
IC50
66000±n/a nM
Citation
 Wu, Y; Li, Z; McDonough, MA; Schofield, CJ; Zhang, X Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy. J Med Chem 64:7189-7209 (2021) [PubMed] 
Target
Name:
Hypoxia-inducible factor 1-alpha inhibitor
Synonyms:
FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor
Type:
Enzyme
Mol. Mass.:
40278.92
Organism:
Homo sapiens (Human)
Description:
Q9NWT6
Residue:
349
Sequence:
MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
  
Inhibitor
Name:
BDBM118339
Synonyms:
US8653111, 72
Type:
Small organic molecule
Emp. Form.:
C13H14N8O2
Mol. Mass.:
314.3027
SMILES:
O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-n1ccnn1
Structure:
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