Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50193829
Substrate
n/a
Meas. Tech.
ChEMBL_422337 (CHEMBL908722)
IC50
>10000±n/a nM
Citation
 Cain, JP; Mayorov, AV; Cai, M; Wang, H; Tan, B; Chandler, K; Lee, Y; Petrov, RR; Trivedi, D; Hruby, VJ Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorg Med Chem Lett 16:5462-7 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50193829
Synonyms:
CHEMBL425442 | N-(2-(1H-indol-3-yl)ethyl)-4-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-oxobutanamide
Type:
Small organic molecule
Emp. Form.:
C28H34N4O2
Mol. Mass.:
458.5952
SMILES:
O=C(CCC(=O)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1)NCCc1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: