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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50193887
Substrate
n/a
Meas. Tech.
ChEMBL_424208 (CHEMBL908982)
IC50
130±n/a nM
Citation
 Noronha, G; Barrett, K; Cao, J; Dneprovskaia, E; Fine, R; Gong, X; Gritzen, C; Hood, J; Kang, X; Klebansky, B; Li, G; Liao, W; Lohse, D; Mak, CC; McPherson, A; Palanki, MS; Pathak, VP; Renick, J; Soll, R; Splittgerber, U; Wrasidlo, W; Zeng, B; Zhao, N; Zhou, Y Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors. Bioorg Med Chem Lett 16:5546-50 (2006) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50193887
Synonyms:
7-(2,6-dimethylphenyl)-5,6-dimethyl-N-phenylbenzo[e][1,2,4]triazin-3-amine | CHEMBL221975 | US8481536, 320
Type:
Small organic molecule
Emp. Form.:
C23H22N4
Mol. Mass.:
354.4476
SMILES:
Cc1cccc(C)c1-c1cc2nnc(Nc3ccccc3)nc2c(C)c1C |(25.05,-20.16,;23.71,-20.93,;22.38,-20.16,;21.05,-20.93,;21.05,-22.48,;22.39,-23.24,;22.39,-24.78,;23.71,-22.48,;25.04,-23.25,;26.37,-22.48,;27.71,-23.24,;29.04,-22.46,;30.38,-23.23,;30.39,-24.79,;31.73,-25.55,;31.73,-27.09,;30.41,-27.86,;30.41,-29.4,;31.75,-30.16,;33.08,-29.38,;33.07,-27.84,;29.05,-25.56,;27.71,-24.79,;26.37,-25.56,;26.37,-27.1,;25.04,-24.79,;23.71,-25.56,)|
Structure:
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