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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50194845
Substrate
n/a
Meas. Tech.
ChEMBL_424572 (CHEMBL853923)
IC50
86±n/a nM
Citation
 Swain, CJ; Teran, A; Maroto, M; Cabello, A Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands. Bioorg Med Chem Lett 16:6058-62 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50194845
Synonyms:
7-(2,4-difluorophenyl)-N-(3-ethylpentan-3-yl)-2,3-dihydro-1H-1,4-diazepin-5-amine | CHEMBL218587
Type:
Small organic molecule
Emp. Form.:
C18H25F2N3
Mol. Mass.:
321.408
SMILES:
CCC(CC)(CC)NC1=NCCN=C(C1)c1ccc(F)cc1F |c:12,t:8|
Structure:
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