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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50196041
Substrate
n/a
Meas. Tech.
ChEMBL_411205 (CHEMBL907225)
IC50
3300±n/a nM
Citation
 Betz, SF; Lio, FM; Gao, Y; Reinhart, GJ; Guo, Z; Mesleh, MF; Zhu, YF; Struthers, RS Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modeling. J Med Chem 49:6170-6 (2006) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50196041
Synonyms:
1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-6-(4-(4,5-dihydro-1H-imidazol-2-ylamino)phenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | CHEMBL387006
Type:
Small organic molecule
Emp. Form.:
C37H32F2N6O2S
Mol. Mass.:
662.751
SMILES:
CN(Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccccc3)c(=O)c12)-c1ccc(NC2=NCCN2)cc1)Cc1ccccc1 |t:38|
Structure:
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