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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50196457
Substrate
n/a
Meas. Tech.
ChEMBL_431931 (CHEMBL917826)
Ki
11±n/a nM
Citation
 Kaur, N; Monga, V; Lu, X; Gershengorn, MC; Jain, R Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Bioorg Med Chem 15:433-43 (2006) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRFR_HUMAN | TRH-R | TRHR | Thyroliberin receptor
Type:
PROTEIN
Mol. Mass.:
45093.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_431933
Residue:
398
Sequence:
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
  
Inhibitor
Name:
BDBM50196457
Synonyms:
(2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6-oxohexahydro-2-pyridinylcarboxamido]propanoyl}azoazolane-2-carboxamide | CHEMBL390942
Type:
Small organic molecule
Emp. Form.:
C19H28N6O4
Mol. Mass.:
404.4634
SMILES:
CCn1cnc(C[C@H](NC(=O)[C@@H]2CCCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1
Structure:
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