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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50196449
Substrate
n/a
Meas. Tech.
ChEMBL_431932 (CHEMBL917827)
Ki
21000±n/a nM
Citation
 Kaur, N; Monga, V; Lu, X; Gershengorn, MC; Jain, R Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Bioorg Med Chem 15:433-43 (2006) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
Thyrotropin-releasing hormone receptor 2
Type:
PROTEIN
Mol. Mass.:
39044.21
Organism:
Rattus norvegicus
Description:
ChEMBL_532304
Residue:
352
Sequence:
MDGPSNVSLIHGDTTLGLPEYKVVSVFLVLLVCTLGIVGNAMVILVVLTSRDMHTPTNCYLVSLALADLLVLLAAGLPNVSDSLVGHWIYGRAGCLGITYFQYLGINVSSFSILAFTVERYIAICHPLRAQTVCTVARAKRIIAGIWGVTSLYCLLWFFLVDLNVRDNQRLECGYKVPRGLYLPIYLLDFAVFFIGPLLVTLVLYGLIGRILFQSPLSQEAWQKERQPHGQSEAAPGNCSRAKSSRKQATRMLAVVVLLFAVLWTPYRTLVLLNSFVAQPFLDPWVLLFCRTCVYTNSAVNPVVYSLMSQKFRAAFLKLCWCRAAGPQRRAARVLTSNYSAAQETSEGTEKM
  
Inhibitor
Name:
BDBM50196449
Synonyms:
(2S)-1-{(2S)-3-(1-allyl-1H-4-imidazolyl)-2-[(2S)-6-oxohexahydro-2-pyridinylcarboxamido]propropanoyl}azolane-2-carboxamide | CHEMBL388528
Type:
Small organic molecule
Emp. Form.:
C20H28N6O4
Mol. Mass.:
416.4741
SMILES:
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(CC=C)cn1)NC(=O)[C@@H]1CCCC(=O)N1
Structure:
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