Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50610935
Substrate
n/a
Meas. Tech.
ChEMBL_2282480
EC50
10.0±n/a nM
Citation
 Wu, X; Yang, X; Liang, Q; Xue, X; Huang, J; Wang, J; Xu, Y; Tong, R; Liu, M; Zhou, Q; Shi, J Drugs for the treatment of glaucoma: Targets, structure-activity relationships and clinical research. Eur J Med Chem 226:0 (2021) [PubMed] 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50610935
Synonyms:
DE-126 | ONO-9054 | Ono-9054 | SEPETAPROST | STN-1012600 | STN1012600 | Sepetaprost
Type:
Small organic molecule
Emp. Form.:
C26H36F2O6
Mol. Mass.:
482.5572
SMILES:
[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3cc(F)ccc3F)[C@@]1([H])CC[C@H](CCCC(=O)OC(C)C)CO2
Structure:
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