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Target
Eukaryotic initiation factor 4A-I
Ligand
BDBM50610942
Substrate
n/a
Meas. Tech.
ChEMBL_2282705
IC50
26590±n/a nM
Citation
 Zerio, CJ; Cunningham, TA; Tulino, AS; Alimusa, EA; Buckley, TM; Moore, KT; Dodson, M; Wilson, NC; Ambrose, AJ; Shi, T; Sivinski, J; Essegian, DJ; Zhang, DD; Schürer, SC; Schatz, JH; Chapman, E Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action. J Med Chem 64:15727-15746 (2021) [PubMed] 
Target
Name:
Eukaryotic initiation factor 4A-I
Synonyms:
ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I
Type:
PROTEIN
Mol. Mass.:
46146.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_864983
Residue:
406
Sequence:
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
  
Inhibitor
Name:
BDBM50610942
Synonyms:
CHEMBL5267864
Type:
Small organic molecule
Emp. Form.:
C24H20BrNO3
Mol. Mass.:
450.325
SMILES:
CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(Br)ccc2n1
Structure:
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