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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50198059
Substrate
n/a
Meas. Tech.
ChEMBL_432539 (CHEMBL918833)
Ki
229±n/a nM
Citation
 Collina, S; Loddo, G; Urbano, M; Linati, L; Callegari, A; Ortuso, F; Alcaro, S; Laggner, C; Langer, T; Prezzavento, O; Ronsisvalle, G; Azzolina, O Design, synthesis, and SAR analysis of novel selective sigma1 ligands. Bioorg Med Chem 15:771-83 (2006) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50198059
Synonyms:
(E)-N,N-dimethyl-3-(6-hydroxy-naphthalen-2-yl)but-2-en-1-yl-amine | CHEMBL223969
Type:
Small organic molecule
Emp. Form.:
C16H19NO
Mol. Mass.:
241.3282
SMILES:
CN(C)C\C=C(/C)c1ccc2cc(O)ccc2c1
Structure:
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